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RHR: Why Microglia Are the Key to Brain Health, with Dr. David Perlmutter

August 11, 2026
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In this episode we discuss: What microglia are and why they’re essential for maintaining healthy brain function How chronic inflammation can transform protective microglia into drivers of neurodegeneration The emerging science of immunometabolism and mitochondrial function Why insulin resistance, obesity, and type 2 diabetes dramatically increase dementia risk The limitations of the traditional amyloid hypothesis and what newer research suggests How lifestyle interventions have demonstrated measurable improvements in cognitive outcomes The powerful connection between the gut microbiome, systemic inflammation, and brain health Why sleep, exercise, and nutrition remain the most impactful tools for protecting the brain The truth about the APOE4 gene—and why genetics are not destiny Show notes: [embedded content] There’s been a lot of discussion about brain health over the past several years, and particularly in the context of dementia and cognitive decline....

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RHR: Your Mouth is Talking To Your Brain—And You Should Be Listening

July 7, 2026
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In this episode we discuss: The connection between periodontal disease and cognitive decline How oral bacteria may access and influence the brain The emerging evidence linking periodontal disease and Alzheimer’s disease The role of Porphyromonas gingivalis and gingipains in neurodegeneration The newly identified oral-gut-brain pathway and microbiome disruption What current research suggests about oral health and Parkinson’s disease The gap between medical and dental care when addressing systemic disease Practical prevention strategies to support oral and cognitive health Show notes: “Oral frailty and neurodegeneration in Alzheimer’s disease” by Dibello, V., et al. “Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors” by Dominy, S.S., et al. “Oral health’s inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions” by...

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RHR: Fibermaxxing: Why the Internet’s Hottest Gut Health Trend Gets It Half Right

May 26, 2026
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In this episode we discuss: What the “fibermaxxing” trend gets right—and wrong Why whole-food fiber and isolated fiber supplements are not equivalent The importance of short-chain fatty acids like butyrate for gut health Why microbiome diversity influences fiber tolerance Common symptoms caused by excessive fermentable fiber intake Differences between soluble and insoluble fiber Surprising research linking high fiber intake with diverticulosis prevalence Safer supplemental options for sensitive guts Show notes: “Short chain fatty acids in human gut and metabolic health” by Blaak, E. E., et al “Intestinal fatty acid-binding protein and gut permeability responses to exercise” by March, D. S., et al “A high-fiber diet does not protect against asymptomatic diverticulosis” by Peery, A. F., et al “Diet and supplements and their impact on colorectal cancer” by Pericleous, M., Mandair, D., & Caplin, M. E. “Carbohydrate quality and human...

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RHR: Revisiting the Gut-Immune Axis

May 12, 2026
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In this episode we discuss: The role of the microbiome in immune regulation Intestinal permeability (“leaky gut”) and its systemic effects Lipopolysaccharides and chronic inflammation The link between gut dysfunction and chronic diseases “Inflammaging” and the gut’s role in aging How modern life disrupts gut health Practical strategies to support the gut-immune axis Show notes: “Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review” by Di Vincenzo, F., et al. “Oral supplementation with bovine colostrum decreases intestinal permeability and stool concentrations of zonulin in athletes” by Haląsa, M., et al. “Lactoferrin reduces the risk of respiratory tract infections: a meta-analysis of randomized controlled trials” by Ali, A. S., et al. “Akkermansia muciniphila and gut immune system: a good friendship that attenuates inflammatory bowel disease, obesity, and diabetes” by Rodrigues, V. F., et al. “Aging and inflammation” by...

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RHR: Beyond the Headlines: A Functional Medicine Approach to Microplastics

May 5, 2026
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In this episode we discuss: Where microplastics accumulate in the body and why size matters How exposure happens: food, water, air, and household environments Links between microplastics and cardiovascular risk, inflammation, and dementia Effects on the gut microbiome and systemic health The “Trojan horse” effect: chemical additives like BPA, phthalates, and PFAS Ways to reduce exposure in daily life– food storage, cookware, and household materials The role of diet, sleep, exercise, and detox pathways Targeted support: antioxidants, NAC, sulforaphane, fiber, and binders A functional medicine framework for resilience in a toxic environment Show notes: “Microplastics: A real global threat for environment and food safety: A state of the art review” by Ziani, K., et al. “Microplastics and nanoplastics in atheromas and cardiovascular events” by Marfella, R., et al. “Bioaccumulation of microplastics in decedent human brains” by Nihart, A.J.,...

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RHR: The Sleep Optimization Trap: Are You Tracking Yourself Into Worse Sleep?

April 28, 2026
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In this episode we discuss: What sleep trackers get right—and where they go wrong The rise of orthosomnia and why it’s becoming more common How sleep anxiety triggers cortisol and disrupts rest The “hyperarousal” model of insomnia explained Why perfectionist beliefs about sleep can backfire When sleep tracking is useful—and when it becomes harmful Why CBT-I is the gold standard for insomnia treatment The importance of managing daytime stress for better sleep A new framework: sleep as a biological process, not a performance metric Show notes: “Orthosomnia: Are some patients taking the quantified self too far?” by Baron, K.G., et al “HPA axis activity in patients with chronic insomnia: A systematic review and meta-analysis of case–control studies” by Dressle, R.J., et al. “Dysfunctional beliefs and attitudes about sleep (DBAS) mediate outcomes in dCBT-I on psychological distress, fatigue, and...

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RHR: The GLP-1 Blind Spot: What Ozempic Won’t Do for Your Metabolic Health

April 21, 2026
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In this episode we discuss: How GLP-1 drugs work  Proven benefits, common side effects, and discontinuation rates Emerging long-term risks of GLP-1 use The risk of nutrient deficiencies from reduced food intake Muscle loss & body composition changes Weight regain after discontinuing use The lack of root-cause treatments addressing diet, lifestyle, and metabolic drivers Who benefits most from GLP-1s vs. who may not Using GLP-1s as part of a broader health strategy Show notes: “Discontinuing glucagon-like peptide-1 receptor agonists and body habitus: A systematic review and meta-analysis” by Berg, S., et al “Trajectory of weight regain after cessation of GLP-1 receptor agonists: A systematic review and nonlinear meta-regression” by Budini, B., et al “Nutritional deficiencies and muscle loss in adults with type 2 diabetes using GLP-1 receptor agonists: A retrospective observational study” by Butsch, W.S., et al “Taking back...

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RHR: Shaking Up the Salt Myth

April 14, 2026
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In this episode we discuss: How the anti-salt movement began Major studies that challenge the narrative Why sodium is essential Potential downsides of sodium restriction Who should actually reduce sodium The overlooked role of potassium Tips for choosing a salt and practical takeaways Show notes: “Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies” by Mente, A., et al. “Urinary sodium and potassium excretion and risk of cardiovascular events” by O’Donnell, M. J., et al. “Fatal and nonfatal outcomes, incidence of hypertension, and blood pressure changes in relation to urinary sodium excretion” by Stolarz-Skrzypek, K., et al. “Shaking Up The Salt Myth” series by Kresser, C. Learn more about the Adapt Naturals Core Plus bundle, or take our quiz to see which products best suit...

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RHR: Mouth Taping: Beyond the Hype—What the Science Really Says

April 7, 2026
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In this episode we discuss: Why nasal breathing is the body’s preferred breathing pathway How mouth breathing affects sleep quality, oral health, and airway resistance The latest systematic review on mouth taping and what it found Potential risks of mouth taping, including worsened sleep apnea and suffocation risk with nasal obstruction The phenomenon of “mouth puffing” and how it may worsen sleep apnea Why airway anatomy determines whether mouth taping helps or harms Why mouth taping may work better when combined with other interventions The importance of diagnosing sleep disorders before trying sleep hacks Safer ways to approach mouth taping if you decide to try it Show notes: “Nocturnal mouth-taping and social media: A scoping review of the evidence” by Fangmeyer, S. K., Badger, C. D., & Thakkar, P. G. “Effect of nasal or oral breathing route...

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RHR: Erythritol: The ‘Safe’ Sweetener That’s Anything But

March 31, 2026
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In this episode we discuss: Why erythritol became the go-to sweetener for “sugar-free” and keto products New evidence linking erythritol to increased risk of heart attack and stroke The FDA’s GRAS designation and how it failed to catch long-term risks Gut health effects of sugar alcohols, including IBS-like symptoms Safer alternatives to erythritol, including allulose, pure stevia, and monk fruit When small amounts of real sugar may be less harmful than chronic sweetener use Practical label-reading tips to avoid hidden erythritol and guidance for sweetener use Show notes: [embedded content] Hey everybody, Chris Kresser here. Welcome to another episode of Revolution Health Radio. If you’re trying to lose weight, manage your blood sugar, or follow a keto diet, chances are you’ve reached for products labeled “sugar-free” or “zero calorie.” Maybe it’s a protein...

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